Related Experiment Video
Updated: Aug 23, 2026

A Metadata Extraction Approach for Clinical Case Reports to Enable Advanced Understanding of Biomedical Concepts
Published on: September 20, 2018
ANCA-related crescentic glomerulonephritis in a patient with scleroderma without marked dermatological change and
Mai Tomioka1, Fumihiko Hinoshita, Naoko Miyauchi
1Department of Medicine, International Medical Center of Japan, Tokyo.
Abstract:
A 64-year-old woman with scleroderma without marked dermatological change developed anti-neutrophil cytoplasmic autoantibody (ANCA)-related renal failure. She had neither malignant hypertension nor elevation of plasma renin concentration. Renal biopsy showed crescentic glomerulonephritis (pauci-immune type) and the myeloperoxidase-specific anti-neutrophil cytoplasmic autoantibody (MPO-ANCA) titer was found to be elevated to 757 IU/ml. Methylprednisolone pulse therapy followed by oral prednisolone effectively suppressed renal failure and lowered the MPO-ANCA titer. We believe this is a rare case of ANCA-related renal failure in a patient with scleroderma without marked dermatological change.
Related Concept Videos
Nephrotic Syndrome I : Introduction
Diabetic Nephropathy
Nephrotic Syndrome III : Nursing Management
Nephrotic Syndrome II : Assessment and Medical Management
Rheumatic Heart Disease I: Introduction
Chronic Kidney Disease II: Clinical Manifestations