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Updated: Jul 18, 2026

Transplantation of Olfactory Ensheathing Cells to Evaluate Functional Recovery after Peripheral Nerve Injury
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[Long-term follow-up of autogenous fat injection for unilateral vocal cord paralysis].

Wu Wen1, Shui-miao Zhou, Xin-qing Yang

  • 1Department of Otorhinolaryngology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China. Wenwu@smmu.edu.cn

Zhonghua Er Bi Yan Hou Ke Za Zhi
|July 31, 2004
PubMed
Summary

Autologous fat injection effectively treats unilateral vocal cord paralysis, with reliable long-term results. This vocal cord volume restoration improves hoarseness and voice quality consistently over time.

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Area of Science:

  • Otolaryngology
  • Regenerative Medicine

Context:

  • Unilateral vocal cord paralysis significantly impairs voice quality.
  • Current treatments aim to restore vocal fold function and medialization.

Purpose:

  • To evaluate the long-term efficacy and reliability of autologous fat injection for unilateral vocal cord paralysis.

Summary:

  • Twenty patients with unilateral vocal cord paralysis underwent autologous fat injection into the thyroarytenoid muscle.
  • Postoperative follow-up exceeded 12 months, utilizing videolaryngoscopy and voice analysis.
  • Objective measurements showed increased vocal cord volume and improved hoarseness and normalized noise energy (NNE).

Impact:

  • Autologous fat injection is a safe and effective treatment for unilateral vocal cord paralysis.

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  • The procedure offers reliable, sustained functional improvement in voice quality.
  • This technique provides a viable option for vocal cord medialization and restoration.