Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Calcium handling in afferent arterioles.

M Salomonsson1, C M Sorensen, W J Arendshorst

  • 1Department of Medical Physiology, Division of Renal and Cardiovascular Research, The Panum Institute, University of Copenhagen, Copenhagen, Denmark.

Acta Physiologica Scandinavica
|July 31, 2004
PubMed
Summary

Intracellular calcium concentration regulates vascular smooth muscle tone. This review focuses on agonist-induced calcium recruitment in afferent arterioles, emphasizing voltage-sensitive calcium channel control.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dynamic changes in renal sodium handling during sympathetic stimulation in healthy human males.

Autonomic neuroscience : basic & clinical·2023
Same author

The Proportion of FceRI+ Blood Monocytes Increases With the Degree of IgE-Mediated Sensitization in Asthma.

Journal of investigational allergology & clinical immunology·2022
Same author

Large-vessel giant cell arteritis after COVID-19 vaccine.

Scandinavian journal of rheumatology·2021
Same author

A method for assessment of the dynamic response of the arterial baroreflex.

Acta physiologica (Oxford, England)·2017
Same author

Kinetic percolation.

Physical review. E·2017
Same author

Myoendothelial coupling through Cx40 contributes to EDH-induced vasodilation in murine renal arteries: evidence from experiments and modelling.

Acta physiologica (Oxford, England)·2017

Area of Science:

  • Physiology
  • Nephrology
  • Cardiovascular Biology

Background:

  • Cytosolic intracellular calcium concentration ([Ca(2+)](i)) is crucial for vascular smooth muscle tone.
  • Agonists activate G-protein coupled receptors, recruiting Ca(2+) via intracellular stores and plasma membrane entry in afferent arterioles.
  • The balance of Ca(2+) entry versus mobilization varies with agonists, species, and preparations.

Purpose of the Study:

  • To review agonist-induced afferent arteriolar calcium recruitment.
  • To emphasize the control mechanisms of voltage-sensitive calcium entry.
  • To explore the roles of K(+) and Cl(-) channels in regulating afferent arteriolar smooth muscle membrane potential.

Main Methods:

  • Literature review of agonist-induced Ca(2+) recruitment in afferent arterioles.

Related Experiment Videos

  • Analysis of the relative importance of Ca(2+) entry and intracellular release.
  • Examination of the role of ion channels (K(+) and Cl(-)) in membrane potential control.

    • Main Results:

    • Voltage-sensitive calcium channels (L-type, T-type, P/Q) and potentially non-voltage-sensitive pathways mediate Ca(2+) entry.
    • Calcium-activated chloride (Cl(Ca)) channels and various K(+) channels are implicated in regulating afferent arteriolar tone.
    • Existing literature is sparse and inconclusive, necessitating further investigation.

    Conclusions:

    • Understanding Ca(2+) regulation in afferent arterioles is vital for controlling renal function, blood pressure, and fluid volume.
    • Further research is needed to clarify the precise roles of different ion channels in afferent arteriolar smooth muscle function.