Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Volume natriuresis vs. pressure natriuresis.

P Bie1, S Wamberg, M Kjolby

  • 1Physiology and Pharmacology, Institute of Medical Biology, University of Southern Denmark, Winslowparken, Odense C, Denmark.

Acta Physiologica Scandinavica
|July 31, 2004
PubMed
Summary

Body fluid balance relies on kidney function. This study suggests sodium regulation is primarily neurohumoral, involving extracellular volume and neural control of the renin system, rather than solely pressure natriuresis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Activation of RAAS in a rat model of liver cirrhosis: no effect of losartan on renal sodium excretion.

BMC nephrology·2018
Same author

Bringing European physiologists together.

Acta physiologica (Oxford, England)·2018
Same author

[Clinical application of combined hepatic artery resection and reconstruction in surgical treatment for hilar cholangiocarcinoma].

Zhonghua wai ke za zhi [Chinese journal of surgery]·2018
Same author

Chronic maternal inflammation or high-fat-feeding programs offspring obesity in a sex-dependent manner.

International journal of obesity (2005)·2017
Same author

IFI16 is required for DNA sensing in human macrophages by promoting production and function of cGAMP.

Nature communications·2017
Same author

The water channel AQP1 is expressed in human atherosclerotic vascular lesions and AQP1 deficiency augments angiotensin II-induced atherosclerosis in mice.

Acta physiologica (Oxford, England)·2017

Area of Science:

  • Physiology
  • Renal Physiology
  • Homeostasis

Background:

  • Body fluid regulation is crucial for survival, involving rapid vasopressin-mediated water balance and slower renin-angiotensin aldosterone-driven sodium retention.
  • The precise sensory mechanisms for sodium control remain elusive, with potential effectors including renal arterial pressure, reflexes, and hormones.
  • Pressure natriuresis has been a central concept for decades, explaining blood pressure-sodium excretion relationships, though dissociations exist.

Purpose of the Study:

  • To investigate the orchestration of sodium homeostasis under chronic and acute sodium loading conditions.
  • To determine the role of pressure natriuresis versus other regulatory mechanisms in controlling sodium excretion.
  • To explore the potential for significant augmentation of renal sodium excretion without altering arterial pressure.

Related Experiment Videos

Main Methods:

  • Studied sodium homeostasis in normal humans and trained dogs using chronic and acute sodium loading protocols.
  • Monitored changes in arterial blood pressure and renal sodium excretion in response to sodium loading.
  • Analyzed the capacity to increase sodium excretion independent of arterial pressure fluctuations.

Main Results:

  • Acute sodium loading can increase arterial blood pressure, with dogs showing higher sensitivity than humans.
  • Renal sodium excretion can be augmented significantly (over one order of magnitude) acutely without changes in arterial pressure.
  • Pressure natriuresis, while powerful, may not be the primary operative mechanism under normal physiological conditions.

Conclusions:

  • Physiological control of sodium excretion appears to be primarily neurohumoral, driven by extracellular volume.
  • Neural control of renin system activity is a key component of sodium homeostasis.
  • Alternative mechanisms beyond pressure natriuresis likely govern sodium balance in normal states.