Related Experiment Video
Updated: Aug 23, 2026

An Integrated Approach for Microprotein Identification and Sequence Analysis
Published on: July 12, 2022
CLANS: a Java application for visualizing protein families based on pairwise similarity
Tancred Frickey1, Andrei Lupas
1Max Planck Institut fuer Entwicklungsbiologie, Spemannstrasse 35, 72076 Tuebingen, Germany.
Summary:
The main source of hypotheses on the structure and function of new proteins is their homology to proteins with known properties. Homologous relationships are typically established through sequence similarity searches, multiple alignments and phylogenetic reconstruction. In cases where the number of potential relationships is large, for example in P-loop NTPases with many thousands of members, alignments and phylogenies become computationally demanding, accumulate errors and lose resolution. In search of a better way to analyze relationships in large sequence datasets we have developed a Java application, CLANS (CLuster ANalysis of Sequences), which uses a version of the Fruchterman-Reingold graph layout algorithm to visualize pairwise sequence similarities in either two-dimensional or three-dimensional space.
Availability:
CLANS can be downloaded at http://protevo.eb.tuebingen.mpg.de/download.
More Related Videos
Related Concept Videos
Protein Families
Protein Families
Evolutionary Relationships through Genome Comparisons
Conservation of Protein Domains Over Different Proteins
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to form...
Conservation of Protein Domains
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to form...
Protein Networks
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...

