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Updated: Aug 23, 2026
A Catheter-Related Candida albicans Infection Model in Mouse
Published on: March 22, 2024
Long-term silicone central venous catheters impregnated with minocycline and rifampin decrease rates of
Hend Hanna1, Robert Benjamin, Ioannis Chatzinikolaou
1The University of Texas M.D. Anderson Cancer Center, Department of Infectious Diseases, 1515 Holcombe Blvd, Houston, TX 77030, USA. hhanna@mdanderson.org
Purpose:
To evaluate the efficacy of long-term nontunneled silicone catheters impregnated with minocycline and rifampin (M-R) in reducing catheter-related bloodstream infections.
Patients And Methods:
This prospective, randomized, double-blind clinical trial was conducted at M.D. Anderson Cancer Center, a tertiary care hospital in Houston, TX. All patients in the trial had a malignancy.
Results:
Between September 1999 and May 2002, 356 assessable catheters were used: 182 M-R and 174 nonimpregnated. The patients' characteristics were comparable between the two study groups. The mean (+/- standard deviation) duration of catheterization with M-R catheters was comparable to that of nonimpregnated catheters (66.21 +/- 30.88 v 63.01 +/- 30.80 days). A total of 17 catheter-related bloodstream infections occurred during the course of the study. Three were associated with the use of M-R catheters and 14 were associated with the nonimpregnated catheters, with a rate of catheter-related bloodstream infection of 0.25 and 1.28/1,000 catheter-days, respectively (P = .003). Gram-positive cocci accounted for the majority of the organisms causing the infections. There were no allergic reactions associated with M-R catheters.
Conclusion:
Long-term nontunneled central venous catheters impregnated with minocycline and rifampin are efficacious and safe in reducing catheter-related bloodstream infections in cancer patients.
