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Published on: July 14, 2023
[Multilocular erythema migrans in borreliosis]
1Universitätskinderklinik der RWTH Aachen. skrischer@ukaachen.de
Background:
Borreliosis is the most common vector transmitted disease in childhood. Although the disease manifests with an erythema migrans in 80 % of the patients, multilocular skin manifestations are only observed in 2-18 % of these. Differential diagnoses of erythema migrans include erysipelas, persistent insect bite reaction, and fixed drug eruption, in particular when the clinical history does not reveal a tick bite.
Patient:
We report on a 5-year-old boy showing nine erythemas with central pallor on his face, trunk, arms and legs. He recalled a tick bite 3 weeks before.
Results:
Serological studies revealed an acute infection with Borrelia burgdorferi. After antibiotic treatment with orally administered amoxicillin skin manifestations resolved within three days. During a follow-up period of six months the patient revealed no signs of persistent borreliosis.
Conclusion:
Multilocular erythema migrans is a possible manifestation of borreliosis and is classified as disseminated early infection which is frequently associated with systemic reactions, including malaise, arthritis, carditis, headache and even meningeal signs. Treatment is based on antibiotics, which should preferably be given intravenously in case of systemic signs.
Insights
Multilocular erythema migrans, a rare skin manifestation of Lyme disease (borreliosis), can occur in children. Prompt antibiotic treatment effectively resolves these disseminated early infection symptoms.
Area of Science:
- Pediatric infectious diseases
- Dermatology
- Vector-borne illnesses
Background:
- Borreliosis is the most common childhood vector-borne disease.
- Erythema migrans occurs in 80% of cases, but multilocular lesions are rare (2-18%).
- Differential diagnoses include erysipelas, insect bite reactions, and drug eruptions, especially without a clear tick bite history.
Observation:
- A 5-year-old boy presented with nine erythema migrans lesions on his face, trunk, arms, and legs.
- The patient reported a tick bite three weeks prior to presentation.
- Lesions were characterized by central pallor.
Findings:
- Serological tests confirmed an acute Borrelia burgdorferi infection.
- Oral amoxicillin treatment led to the resolution of skin manifestations within three days.
- No signs of persistent borreliosis were observed during a six-month follow-up.
Implications:
- Multilocular erythema migrans represents a disseminated early Lyme disease infection.
- This manifestation can be associated with systemic symptoms like malaise, arthritis, carditis, headache, and meningeal signs.
- Antibiotic therapy is crucial; intravenous administration is preferred for systemic involvement.
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