Related Experiment Video
Updated: Aug 23, 2026

Rapid Glyco-Qualitative Assessment of Recombinant Proteins Using a Fully Automated System
Published on: June 28, 2024
[Phylogenetic analysis of alpha-galactosidases of the GH27 family]
Abstract:
Amino acid sequence analysis of alpha-galactosidases and other proteins of glycoside hydrolase family 27 (GH27) allowed isolation of three major subfamilies, 27a-27c. Unique isomalto-dextranase of Arthrobacter globiformis clustered separately. Eukaryotic proteins formed five clusters on a phylogenetic tree of the family. Bacterial GH27 proteins, which are relatively few, did not form stable clusters. A monophyletic origin of the GH27 family was demonstrated with the use of related proteins of the GH36 family. The structure of the active center and evolution of alpha-galactosidases are discussed.
Related Concept Videos
Protein Families
Evolutionary Relationships through Genome Comparisons

