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Related Experiment Videos

Anaphylaxis in immunotherapy.

W E Davis, P R Cook, J P McKinsey

    Otolaryngology--Head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
    |July 1, 1992
    PubMed
    Summary
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    Anaphylactic reactions from immunotherapy are rare but can be severe. A 5-year review found 14% of patients experienced mild reactions, with no fatalities reported.

    Area of Science:

    • Allergy and Immunology
    • Clinical Medicine
    • Pharmacology

    Background:

    • Anaphylaxis during immunotherapy is a rare but potentially fatal adverse event.
    • Over 30 deaths linked to immunotherapy have been reported in the literature.
    • Systemic reactions require careful monitoring during allergen immunotherapy.

    Purpose of the Study:

    • To evaluate the incidence and severity of anaphylactic reactions during allergen immunotherapy.
    • To present the experience of a university practice over a 5-year period.
    • To assess the safety profile of immunotherapy in a clinical setting.

    Main Methods:

    • Retrospective review of patient records over a 5-year period.
    • Analysis of over 125,000 immunotherapy injections administered.

    Related Experiment Videos

  • Identification and categorization of systemic reactions, specifically anaphylaxis.

    • Main Results:

    • A total of 550 patients received immunotherapy during the study period.
    • 14% of patients experienced anaphylactic reactions.
    • The majority of reported anaphylactic reactions were mild in severity.

    Conclusions:

    • Allergen immunotherapy can be safely administered with careful monitoring.
    • While rare, anaphylactic reactions are a potential risk associated with immunotherapy.
    • The incidence of mild anaphylactic reactions in this university practice was significant but manageable.