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Is Recormon less painful than Eprex after subcutaneous administration?
M W Hendriks1, F P Peters, P M Hooymans
1Department of Clinical Pharmacy and Toxicology, Maasland Hospital, Sittard, The Netherlands.
Pharmaceutisch Weekblad. Scientific Edition
|April 24, 1992
Summary
Recormon is a less painful alternative to Eprex for subcutaneous injections. Significantly fewer patients reported pain with Recormon compared to Eprex, suggesting improved patient comfort.
Area of Science:
- Pharmacology
- Pain Management
- Biotechnology
Background:
- Epoetin preparations are crucial for treating anemia.
- Subcutaneous injection is a common administration route.
- Patient-reported pain is a significant factor in treatment adherence.
Purpose of the Study:
- To compare pain scores between Eprex and Recormon after subcutaneous injection.
- To identify potential differences in patient-reported pain for epoetin formulations.
Main Methods:
- A randomized, double-blind study involving 30 patients.
- Each patient received 5 subcutaneous injections of Eprex and 5 of Recormon.
- Pain was assessed using visual analogue, verbal analogue, and descriptive scales 10 minutes post-injection.
Main Results:
- Significantly more patients reported pain with Eprex (11) than Recormon (2) (p < 0.05).
- A higher proportion of Recormon injections (69/125) were pain-free compared to Eprex (43/123) (p < 0.01).
- Recormon was significantly less painful for 4 patients (p < 0.05).
Conclusions:
- Recormon may offer a less painful subcutaneous injection experience compared to Eprex.
- This finding could improve patient adherence and comfort in anemia management.
- Individualized assessment of pain is recommended for epoetin therapy.