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Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
Interferon induced Autoimmune Thyroid Disease (AITD): a model for human autoimmunity
Yael Oppenheim1, Yoshiyuki Ban, Yaron Tomer
1Division of Endocrinology, Diabetes, and Bone Diseases, Mount Sinai School of Medicine, P.O. Box 1055, One Gustave L. Levy Place, New York, NY 10029, USA.
Abstract:
Interferon (IFN) alpha treatment for various conditions has been associated with thyroid autoimmunity. The incidence of interferon induced thyroid autoimmunity has been reported to range from 2.5% to 42%, possibly depending upon dose and duration of medical therapy and patient characteristics. It is not known whether IFN-alpha initiates autoimmune thyroid disease (AITD) or simply exacerbates AITD in individuals with subclinical AITD.
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