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Cancer Therapies

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

Combination Therapies and Personalized Medicine

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

Combination Therapies and Personalized Medicine

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

Combined Effects of Drugs: Antagonism

Combined Effects of Drugs: Antagonism

The combined effects of drugs can result in various interactions, of which an important type is antagonism. Antagonism is a mechanism where one drug inhibits or counteracts the effects of another drug. Antagonism can occur through various means, including receptor binding, allosteric modulation, functional interaction, chemical reactions, and pharmacokinetic processes.
The most common type is receptor antagonism, where one drug acts as an antagonist to block the effects of another drug by...

Pharmacokinetics: Drug–Drug Interactions

Pharmacokinetics: Drug–Drug Interactions

Drug interactions occur when the pharmacological effect of one drug is altered by another substance, either enhancing or diminishing its activity. The drug whose activity is altered is known as the object drug, and the substance causing the alteration is called the agent drug or the precipitant. The net effects of these interactions are mostly undesirable, leading to decreased effectiveness or increased adverse effects. In rare cases, interactions can be beneficial, such as the enhanced...

Drug toxicity: Drug–Drug Interaction

Drug toxicity: Drug–Drug Interaction

Drug–drug interactions can precipitate toxicity through multiple mechanisms. Absorption interactions alter how drugs enter the body, exemplified when ranitidine increases the absorption of basic drugs, while cholestyramine decreases the levels of propranolol. Protein binding interactions occur when drugs share the same binding sites on plasma proteins. Drugs like aspirin and warfarin, when bound in excess, can lead to increased free drug concentrations, enhancing the potential for...

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Related Experiment Video

Updated: Jun 19, 2026

Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice

Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice

Published on: October 5, 2017

Drug interactions in oncology.

Jos H Beijnen¹, Jan H M Schellens

¹Department of Pharmacy and Pharmacology, Slotervaart Hospital, The Netherlands Cancer Institute, Amsterdam, The Netherlands. Apjby@slz.nl

The Lancet. Oncology

|August 4, 2004

Summary

Understanding drug interactions is crucial for cancer treatment. This review highlights potential pharmaceutical, pharmacokinetic, and pharmacodynamic interactions involving anticancer drugs, emphasizing early detection.

Area of Science:

Oncology
Pharmacology
Drug Interactions

Background:

Drug interactions pose significant risks in cancer therapy, particularly with cytotoxic agents.
The clinical significance of many drug interactions remains under-investigated.
Interactions can be categorized as pharmaceutical, pharmacokinetic, or pharmacodynamic, and can be intended or unintended.

Purpose of the Study:

To provide a comprehensive overview of drug interactions relevant to cancer treatment.
To highlight the importance of recognizing potential interactions early in drug development.
To present selected examples of drug interactions in oncology.

Main Methods:

Literature review of drug interactions in cancer therapy.
Categorization of drug interactions (pharmaceutical, pharmacokinetic, pharmacodynamic).

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Inclusion of examples of wanted and unwanted drug interactions.

Main Results:

Drug interactions can occur between cytotoxic drugs, non-cytotoxic drugs, and even over-the-counter products or herbal medicines.
Fatal complications can arise from specific drug combinations (e.g., sorivudine and fluorouracil analogues).
Some interactions are intentionally used to improve drug efficacy (e.g., ciclosporin with paclitaxel).

Conclusions:

Potential drug interactions in cancer treatment require greater attention.
Early identification of drug interactions during preclinical and clinical development is essential.
A thorough understanding of drug interactions is vital for patient safety in oncology.