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Viral interactions with the Notch pathway.

S Diane Hayward1

  • 1Viral Oncology Program, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, School of Medicine, CRB 308, 1650 Orleans Street, Baltimore, MD 21231, USA. dhayward@jhmi.edu

Seminars in Cancer Biology
|August 4, 2004
PubMed
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Viruses interact with the Notch signaling pathway to advance their life cycles. This review highlights herpesvirus interactions with Notch, revealing insights into viral manipulation of cellular processes.

Area of Science:

  • Virology
  • Cell Biology
  • Molecular Biology

Background:

  • The Notch signaling pathway regulates crucial cellular processes including cell fate, proliferation, differentiation, and survival.
  • Viruses often manipulate host cell differentiation, cell cycling, and survival mechanisms to facilitate their replication and evade immune responses.
  • Commonalities in cellular process regulation suggest potential viral exploitation of host pathways like Notch.

Purpose of the Study:

  • To review and summarize the interactions between herpesviruses and the Notch signaling pathway.
  • To explore the functional implications of these interactions for both viral life cycles and host cell biology.
  • To provide insights gained from studying these viral-Notch pathway connections.

Main Methods:

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  • Literature review focusing on studies investigating viral protein interactions with Notch pathway components.
  • Analysis of reported binding partners and functional consequences of these interactions.
  • Synthesis of findings related to Epstein-Barr virus, Kaposi's sarcoma-associated herpesvirus, adenovirus, SV40, and human papilloma virus.

    • Main Results:

    • Several viruses, including herpesviruses, have been shown to interact with the Notch signaling pathway.
    • Epstein-Barr virus proteins target CSL (also known as CBF1/RBPJk), a key nuclear effector of Notch signaling.
    • The Kaposi's sarcoma-associated herpesvirus RTA protein directly binds to CSL, indicating a direct viral manipulation mechanism.

    Conclusions:

    • Herpesvirus interactions with the Notch pathway are significant for viral propagation and survival.
    • These interactions offer valuable insights into how viruses subvert host cell machinery.
    • Further research into viral-Notch crosstalk can illuminate fundamental aspects of cell signaling and viral pathogenesis.