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Related Experiment Videos

Remote memory in advanced Alzheimer's disease.

Giuseppe Sartori1, Beth E Snitz, Linda Sorcinelli

  • 1Dipartimento di Psicologia Generale, Università di Padova, Via Venezia 8, 35100 Padova, Italy. giuseppe.satori@unipd.it

Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists
|August 4, 2004
PubMed
Summary

This study shows that individuals with advanced Alzheimer's disease (dementia of Alzheimer type) have significant impairments in remote memory, including autobiographical memory and public events. Some executive functions may support remaining memory abilities.

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Area of Science:

  • Neuroscience
  • Psychology
  • Gerontology

Background:

  • Alzheimer's disease (AD) is a progressive neurodegenerative disorder.
  • Dementia of Alzheimer type (DAT) significantly impacts cognitive functions, including memory.
  • Remote memory, encompassing autobiographical and public events, is crucial for understanding AD's cognitive profile.

Purpose of the Study:

  • To investigate remote memory functioning in patients with advanced dementia of Alzheimer type (DAT).
  • To assess autobiographical memory, public event recognition, and famous face recognition in DAT.
  • To explore the relationship between remote memory and executive functioning in advanced DAT.

Main Methods:

  • Ten DAT patients with Mini-Mental State Exam (MMSE) scores below 15 were recruited.

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  • Remote memory was assessed using the Autobiographical Memory Enquiry (AME) and autobiographical fluency (AF).
  • Recognition of remote public events and famous faces was also evaluated, alongside semantic fluency measures.

    • Main Results:

    • DAT patients demonstrated significant impairments across all remote memory measures compared to healthy controls.
    • Autobiographical fluency for names was only borderline impaired in DAT patients.
    • A better preservation of early public-event memory over recent events was observed in both groups, with a correlation between semantic fluency and remote memory in DAT patients.

    Conclusions:

    • Advanced dementia of Alzheimer type (DAT) exhibits a minimal outline of preserved remote memory.
    • Executive functioning appears to be associated with remote memory performance in individuals with advanced DAT.
    • Findings highlight the complex nature of memory decline in Alzheimer's disease.