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Sound sequence discrimination learning is dependent on cholinergic inputs to the rat auditory cortex.

Masaharu Kudoh1, Kenjiro Seki, Katsuei Shibuki

  • 1Department of Neurophysiology, Brain Research Institute, Niigata University, 1-757 Asahimachi, Niigata 951-8585, Japan. kudoh@bri.niigata-u.ac.jp

Neuroscience Research
|August 4, 2004
PubMed
Summary

Cholinergic inputs in the auditory cortex are crucial for learning sound sequences. Inhibiting these pathways impairs learning, but this effect can be reversed, suggesting a role for synaptic plasticity.

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Area of Science:

  • Neuroscience
  • Auditory Cortex Research
  • Synaptic Plasticity

Background:

  • Synaptic potentiation in the auditory cortex (AC) exhibits sequence-dependent plasticity.
  • This plasticity is modulated by cholinergic inputs and is abolished by muscarinic receptor antagonists.
  • Sequence-dependent plasticity is hypothesized to contribute to the cellular mechanisms of sound sequence discrimination.

Purpose of the Study:

  • To investigate the role of cholinergic inputs in the rat AC for sound sequence discrimination learning.
  • To determine if sequence-dependent synaptic plasticity in the AC is involved in auditory learning.

Main Methods:

  • Rats were trained to discriminate between two sound sequences.
  • Muscarinic receptor antagonist (atropine) and cholinergic immunotoxin (192IgG-saporin) were used to assess the role of cholinergic input.

Related Experiment Videos

  • M-current inhibitor (linopirdine) was administered to evaluate its effect on learning and plasticity.

    • Main Results:

    • Atropine attenuated sound sequence discrimination learning, but not previously acquired discrimination.
    • 192IgG-saporin injections suppressed sound sequence discrimination learning without affecting basic sound component discrimination.
    • Linopirdine restored sound sequence discrimination learning impaired by 192IgG-saporin.

    Conclusions:

    • Cholinergic inputs to the rat AC are essential for learning sound sequences.
    • Sequence-dependent synaptic plasticity in the AC plays a role in the cellular mechanisms underlying sound sequence discrimination learning.
    • These findings support the hypothesis linking synaptic plasticity to auditory sequence learning.