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Published on: June 7, 2013
GLUT1-deficient mice exhibit impaired endothelium-dependent vascular relaxation
James L Park1, Charles W Heilig, Frank C Brosius
1Internal Medicine, Division of Nephrology, University of Michigan Medical School, 1560 MSRB 2, 1150 W. Medical Center Drive, Ann Arbor, MI 48109-0676, USA.
Abstract:
We tested the hypothesis that decreased glucose transporter 1 (GLUT1) expression alters endothelial function. Nitric oxide-dependent endothelial relaxation, but not endothelium-independent relaxation, was significantly reduced in aortas from transgenic mice expressing GLUT1 antisense mRNA, compared to aortas from nontransgenic littermates. These data suggest that GLUT1-dependent glucose metabolism may play an important role in regulating endothelial function.
