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Related Experiment Videos

Bladder tumours in rubber workers: a factory study 1946-1995.

C A Veys1

  • 1Primary Care Sciences Research Centre, School of Postgraduate Medicine, Keele University, Keele, UK. veys11@tesco.net

Occupational Medicine (Oxford, England)
|August 4, 2004
PubMed
Summary

British rubber industry workers exposed to beta-naphthylamine showed elevated bladder cancer risk. Removing the carcinogen beta-naphthylamine from antioxidants in 1949 significantly reduced this occupational bladder cancer risk.

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Area of Science:

  • Occupational Health
  • Epidemiology
  • Toxicology

Background:

  • Workers in the British rubber industry were exposed to beta-naphthylamine, a human bladder carcinogen, as a contaminant in antioxidants before December 1949.
  • A cohort of 6450 men from a tyre factory, exposed during or shortly after this period, was studied.

Purpose of the Study:

  • To investigate the association between occupational exposure to beta-naphthylamine and bladder cancer risk in rubber industry workers.
  • To assess the impact of removing the carcinogen on bladder cancer incidence.

Main Methods:

  • A cohort study followed 2090 workers exposed between 1945-1949 and 3038 workers first employed after January 1950.
  • Bladder cancer morbidity and mortality data were collected and compared to national rates.

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  • Work location data was used to interpret findings.

    • Main Results:

    • The exposed group (pre-1950) had 58 registered bladder tumors, significantly higher than the expected 33.9 (SRRN=171).
    • The group first employed after 1950 showed 39 tumors, close to the expected 38.3 (SRRN=102).
    • Mortality data underestimated the risk; morbidity data revealed the elevated risk.

    Conclusions:

    • A statistically significant increased risk of bladder cancer was observed in workers exposed to beta-naphthylamine.
    • This risk diminished after the carcinogen's removal in October 1949.
    • Morbidity data is crucial for accurate assessment of occupational bladder cancer risk.