Acute vanishing bile duct syndrome after ibuprofen therapy in a child
M Taghian1, T A Tran, S Bresson-Hadni
1Pediatric Unit, Vesoul Hospital, Vesoul, France.
The Journal of Pediatrics
|August 4, 2004
Insights
Ibuprofen can cause Stevens-Johnson syndrome and cholestasis, leading to vanishing bile duct syndrome. Treatment with ursodeoxycholic acid helped normalize liver tests in a pediatric patient.
Area of Science:
- Pediatric Hepatology
- Toxicology
- Dermatology
Background:
- Stevens-Johnson syndrome is a severe adverse drug reaction.
- Cholestasis indicates impaired bile flow.
- Vanishing bile duct syndrome is a rare liver condition.
Observation:
- A 10-year-old girl developed Stevens-Johnson syndrome and cholestasis following ibuprofen administration.
- Liver biopsy revealed histological features consistent with vanishing bile duct syndrome.
- The patient was treated with ursodeoxycholic acid.
Findings:
- Ibuprofen therapy was strongly associated with the development of Stevens-Johnson syndrome and cholestasis in this pediatric case.
- The liver histology confirmed vanishing bile duct syndrome as a consequence of the adverse drug reaction.
- Ursodeoxycholic acid treatment facilitated the normalization of liver function tests within a 7-month period.
Implications:
- This case highlights ibuprofen as a potential inducer of acute vanishing bile duct syndrome in children.
- Early recognition and appropriate management, including ursodeoxycholic acid, may be crucial for favorable outcomes in drug-induced cholestasis.
- Further research into the mechanisms of ibuprofen-induced liver injury is warranted to prevent such severe adverse events.
Abstract:
We report the case of a 10 year-old girl who had Stevens-Johnson syndrome and cholestasis after ibuprofen therapy. Liver histology was compatible with vanishing bile duct syndrome. She received ursodeoxycholic acid, and liver tests normalized within 7 months. This report confirms that ibuprofen may induce acute vanishing bile duct syndrome.
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