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Structure-based models of cadherin-mediated cell adhesion: the evolution continues.

A W Koch1, K L Manzur, W Shan

  • 1Montreal Neurological Institute, McGill University, 3801 University Street, H3A 2B4, Montreal, Quebec, Canada. akoch@gene.com

Cellular and Molecular Life Sciences : CMLS
|August 4, 2004
PubMed
Summary

Cadherins are key proteins for cell adhesion. This review reconciles structural studies of cadherin interactions, clarifying their roles in development and neuroscience.

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Area of Science:

  • Molecular Biology
  • Structural Biology
  • Neuroscience

Background:

  • Cadherins are glycoproteins mediating calcium-dependent cell-cell adhesion.
  • These proteins are vital for embryogenesis and neural circuit formation.
  • Previous structural studies offer insights but contain contradictions.

Purpose of the Study:

  • To review structural studies of cadherins over the last decade.
  • To reconcile conflicting findings from earlier cadherin structural research.
  • To provide an updated understanding of cadherin-mediated adhesion.

Main Methods:

  • Literature review of high-resolution structural studies.
  • Analysis of cadherin-cadherin interaction models.
  • Synthesis of recent structural data.

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Main Results:

  • Recent structural data helps resolve discrepancies in cadherin interaction models.
  • A more unified understanding of cadherin adhesion mechanisms is emerging.
  • Key structural features governing cadherin function are highlighted.

Conclusions:

  • Structural biology has significantly advanced our understanding of cadherins.
  • Reconciliation of structural data provides a clearer picture of cadherin function.
  • This review consolidates knowledge on cadherin structure and adhesion.