Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Brain perfusion abnormalities in patients with euthyroid autoimmune thyroiditis.

M Piga1, A Serra, L Deiana

  • 1Nuclear Medicine, Department of Medical Sciences M. Aresu, University of Cagliari, Cagliari, Italy. pigam@pacs.unica.it

European Journal of Nuclear Medicine and Molecular Imaging
|August 4, 2004
PubMed
Summary

This study found brain perfusion abnormalities in most euthyroid patients with Hashimoto

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Optimized synthesis and characterization of highly reproducible carbon dots for bioimaging applications.

Colloids and surfaces. B, Biointerfaces·2025
Same author

Improving efficiency in a total hip arthroplasty program.

Journal of healthcare quality research·2025
Same author

<sup>131</sup>I-mIBG therapy in relapsed/refractory neuroblastoma: an old bridge to the future.

ESMO open·2025
Same author

An ancestral molecular response to nanomaterial particulates.

Nature nanotechnology·2023
Same author

Analysis of Poly(thiourethane) Covalent Adaptable Network through Broadband Dielectric Spectroscopy.

ACS applied polymer materials·2023
Same author

Exploring the relationship between bacterial genera and lipid metabolism in bovine rumen.

Animal : an international journal of animal bioscience·2022

Area of Science:

  • Neurology
  • Endocrinology
  • Radiology

Background:

  • Subtle central nervous system (CNS) involvement is suspected in Hashimoto's thyroiditis (HT), but direct evidence is lacking.
  • Previous studies using single-photon emission computed tomography (SPECT) have shown brain perfusion abnormalities in severe Hashimoto's encephalopathy.
  • This study investigates subclinical CNS involvement in euthyroid HT patients.

Purpose of the Study:

  • To assess cortical brain perfusion in euthyroid patients with Hashimoto's thyroiditis (HT) using 99mTc-ECD SPECT.
  • To determine if subclinical central nervous system (CNS) involvement exists in HT patients without overt neurological symptoms.

Main Methods:

  • 16 adult euthyroid HT patients, 9 with non-toxic nodular goitre (NTNG), and 10 healthy controls underwent 99mTc-ECD brain SPECT.

Related Experiment Videos

  • Diagnosis of HT based on high anti-thyroid antibodies, ultrasound findings, and normal thyroid function.
  • Qualitative and semiquantitative analysis of SPECT images, including calculation of the Asymmetry Index (AI) for cortical perfusion.

    • Main Results:

    • Irregular and patchy cerebral 99mTc-ECD distribution, particularly hypoperfusion in frontal lobes, was observed in HT patients.
    • Brain perfusion abnormalities (AI) were detected in 12/16 HT patients, 3/9 NTNG patients, and 0/10 controls.
    • Significantly higher mean AI in frontal lobes of HT patients compared to both NTNG patients (p<0.003) and healthy controls (p<0.001).

    Conclusions:

    • Euthyroid Hashimoto's thyroiditis is associated with a high prevalence of subclinical brain perfusion abnormalities.
    • These abnormalities resemble those seen in severe Hashimoto's encephalopathy, suggesting significant CNS involvement in autoimmune thyroid disease.
    • Findings indicate a greater than expected impact of thyroid autoimmunity on the central nervous system.