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Second-trimester genetic amniocentesis: 5-year experience.
Nilgün Oztürk Turhan1, Unal Eren, Neslihan Carda Seçkin
1Department of Obstetrics and Gynecology, Fatih University of Medicine, Bilkent 1 Camlik Sitesi, C 9/2, Ankara, Turkey. nilgunturhan@hotmail.com
Archives of Gynecology and Obstetrics
|August 4, 2004
Summary
Second-trimester genetic amniocentesis is a safe and reliable prenatal diagnostic method. This study found complication rates consistent with existing literature, supporting its use in clinical practice.
Area of Science:
- Obstetrics and Gynecology
- Prenatal Diagnosis
- Medical Genetics
Background:
- Second-trimester genetic amniocentesis is a common invasive procedure for prenatal diagnosis.
- Evaluating the safety and efficacy of this procedure is crucial for patient care.
Purpose of the Study:
- To assess the data of genetic amniocentesis procedures performed at a university hospital.
- To analyze indications, complications, and pregnancy outcomes associated with the procedure.
Main Methods:
- Retrospective analysis of medical records from January 1998 to January 2002.
- Inclusion of all patients undergoing anomaly screening between 16-20 weeks gestation.
- All second-trimester genetic amniocentesis procedures were performed by staff obstetricians-gynecologists.
Main Results:
- A total of 131 genetic amniocentesis procedures were performed out of 2,686 patients screened.
- Primary indications included abnormal triple screen (90), advanced maternal age (24), ultrasound abnormalities (15), and family history (2).
- Two pregnancy losses occurred, resulting in a 1.5% complication rate for the procedure.
Conclusions:
- Second-trimester genetic amniocentesis is a reliable and safe invasive prenatal diagnostic technique.
- The observed complication rate of 1.5% aligns with published literature.
- The study supports the continued use of genetic amniocentesis in prenatal care.