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Granulocyte colony-stimulating factor induces disease flare in patients with antineutrophil cytoplasmic

Christof Iking-Konert1, Benedikt Ostendorf, Mark Foede

  • 1Center for Rheumatology, Heinrich-Heine University Duesseldorf, Duesseldorf, Germany. iking-konert@med.uni-duesseldorf.de

The Journal of Rheumatology
|August 4, 2004
PubMed

Recombinant human granulocyte colony-stimulating factor (rhuG-CSF) is frequently given to patients with leukopenia or neutropenia caused by various underlying diseases. The treatment with rhuG-CSF is apparently safe, although cutaneous vasculitis and flares in patients with autoimmune diseases are described. We describe 2 patients with histologically proven antineutrophil cytoplasmic antibody-associated systemic vasculitis with disease flares after administration of rhuG-CSF, given to improve collection of stem cells prior to autologous stem cell transplantation.

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