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Updated: Aug 23, 2026

Formation of Dispersible Taohong Siwu Tablets
Published on: February 3, 2023
Development of dividable one-step dry-coated tablets (dividable-OSDRC) and their evaluation as a new platform for
Yuichi Ozeki1, Yukinao Watanabe, Hirokazu Okamoto
1Pharmaceutical Research & Technology Laboratory, Sanwa Kagaku Kenkyusho Co. Ltd., Gifu-City, Japan. yu_ozeki@skk-net.com
Purpose:
The purpose of this study is to develop novel dividable coated tablets that retain their characteristics even after they are divided.
Methods:
We prepared dividable one-step dry-coated tablets (dividable-OSDRC) using our own manufacturing process with double structure punches. The release pattern of the dividable-OSDRC with hydroxypropyl methylcellulose (HPMC) or methacrylic acid copolymer LD (Eudragit) as an outer layer was investigated before and after the division, and dissolution profiles were statistically compared using difference factor f1 and similarity factor f2.
Results:
The dividable-OSDRC with HPMC for sustained-release (compression pressure, 150 MPa; crashing strength, 6.1 N; friability, 0.05%; CV of divided tablet weight, 7.8%) showed statistically equivalent release patterns between the one-half and the whole (f1, 13.9; f2, 55.5) and between the one-half and the two-halves (5.5, 72.5). The surface area of the tablets affected the sustained-release profiles. Furthermore, the tablets made with Eudragit LD for timed-release (150 MPa. 12.8 N, 0.18%, 9.6%) also showed approximated release patterns before and after the division.
Conclusions:
We proved that dividable-OSDRC maintain their release characteristics after they are divided. We conclude that the dividable-OSDRC could be used as a new platform for the controlled release of drugs.
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