Related Experiment Video
Updated: Aug 23, 2026

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
Published on: February 15, 2022
Acute effects of sildenafil on Humphrey visual field and intraocular pressure
Sitki Samet Ermis1, Umit Ubeyt Inan, Murat Samli
1Department of Ophthalmology, School of Medicine, University of Afyon Kocatepe, Afyon, Turkey. sametermis@hotmail.com
Purpose:
To evaluate the effects of sildenafil on visual field and intraocular pressure in a group of healthy subjects.
Methods:
Twenty-eight healthy male volunteers with normal eyes were included in the study. Visual field examinations were performed using FASTPAC 30-2 program (white-on-white and blue-on-yellow) with the Humphrey field analyzer before and one hour after receiving oral 50 and 100 mg sildenafil citrate.
Results:
The mean age was 51.1 +/- 8.9 years. Mean deviation, pattern standard deviation, short-term fluctuation and corrected pattern standard deviation did not differ significantly among tests both in white-on-white and blue-on-yellow visual field examinations. Changes in intraocular pressure were not statistically significant.
Conclusions:
No significant effect of sildenafil was seen on visual field and intraocular pressure in healthy subjects.
Related Concept Videos
Treatment for Pulmonary Arterial Hypertension: Phosphodiesterase Inhibitors
Among the PDE5 inhibitors, sildenafil (Revatio) stands out as a competitive and selective inhibitor. It operates by elevating cellular levels of cGMP and augmenting signaling through the cGMP-PKG pathway, promoting vasodilation. Upon oral...
Open Angle Glaucoma: Treatment
Drugs such as carbonic anhydrase inhibitors, α2- and...
Glaucoma: Overview
Angle Closure Glaucoma: Treatment
