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[Pathological study of the therapeutic effect of wen-yang herbs on experimental liver cirrhosis]
Li-chun Wang1, Bing-jun Lei, Lin Li
1Department of Infectious Disease, West China Hospital, Sichuan University, Chengdu 610041, China.
Objective:
To observe the pathological effect of wen-yang herbs on experimental hepatic fibrosis.
Methods:
Thirty-two male Wistar rats were used in this study comprising four groups. To start with, 24 rats of three groups were given subcutaneous injection of CCl4 and drinking 10% alcohol so as to make the model of hepatic fibrosis. After the establishment of the pathologic model, the rats were divided into the model group, the pathological control group and the therapeutic group by randomization. The rats of the therapeutic group were given the herbal remedies via gastrogavage, q.d. x 30. The rats of the pathological control group were given normal saline via gastrogavage, q.d. x 30. Then liver tissue Hydroxyproline (Hyp) content was examined in these 3 groups and the normal group. Quantitative marks were done according to a modified semiquantitative scoring system (SSS). The results of SSS marks and Hyp contents were analysed using Pearson's coefficient of correlation.
Results:
The Hyp content and SSS marks of the therapeutic group decreased remarkably as compared with those of the control group (P<0.01), and the SSS marks had a strong positive correlation with Hyp content (r=0.804).
Conclusion:
Wen-yang herbs can mitigate the rats' hepatic fibrosis and promote a recovery of their experimental illness.
