Related Experiment Video
Updated: Jul 9, 2026

14:22
Free Radicals in Chemical Biology: from Chemical Behavior to Biomarker Development
Published on: April 15, 2013
3-nitro-3-deaza-2'-deoxyadenosine as a versatile photocleavable 2'-deoxyadenosine mimic
Caroline Crey-Desbiolles1, Jean Lhomme, Pascal Dumy
1LEDSS, UMR5616 CNRS, ICMG FR-2607 - BP53, Université Joseph Fourier, 38041 Grenoble, France.
Journal of the American Chemical Society
|August 5, 2004
Abstract:
A new photocleavable 2'-deoxyadenosine mimic, 3-nitro-3-deaza-2'-deoxyadenosine (NidA), was prepared and introduced into DNA fragments via its 6-O-trimethylphenyl precursor phophoramidite. Photocleavage of the resulting oligonucleotide is highly efficient in single and double strands. Hybridization properties of NidA are very similar to those of deoxyadenosine.

