The total synthesis of (+)-dragmacidin F

Neil K Garg1, Daniel D Caspi, Brian M Stoltz

  • 1Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.

Related Concept Videos

Fischer Projections02:18

Fischer Projections

Learning to draw Fischer projections of molecules and understanding their relevance plays a crucial role in the visual depiction of organic molecules. A Fischer projection is a two-dimensional projection on a planar surface to simplify the three-dimensional wedge–dash representation of molecules. This is especially helpful in the case of molecules with multiple chiral centers that can be difficult to draw. Here, all the bonds of interest are represented as horizontal or vertical lines. While...
Gravitational Potential Energy for Extended Objects01:07

Gravitational Potential Energy for Extended Objects

Consider a system comprising several point masses. The coordinates of the center of mass for this system can be expressed as the summation of the product of each mass and its position vector divided by the total mass:
The Chain Rule01:30

The Chain Rule

A system of interconnected gears provides a concrete physical interpretation of the Chain Rule in calculus. Consider three gears arranged in sequence, where the rotational speeds of the first, second, and third gears are represented by the variables x, z, and y, respectively. The first gear drives the second, and the second drives the third, so the motion of each gear depends on the one preceding it. This structure naturally leads to a two-stage variable relationship that can be analyzed using...
Combining Functions01:16

Combining Functions

Functions can be combined to form new mathematical models that describe interactions between variables. These combinations are fundamental in understanding relationships between changing quantities and are commonly encountered in scientific and engineering contexts. The combination methods—addition, subtraction, multiplication, division, and composition—each have unique implications for the resulting function’s domain and behavior.When combining functions through arithmetic operations, such...
Multivariable Functions and Higher Derivatives01:30

Multivariable Functions and Higher Derivatives

A multivariable function assigns a single output value to each ordered set of independent inputs, thereby defining a surface in three-dimensional space. For a function f(x, y), each point (x, y) corresponds to a height z = f(x, y). This geometric interpretation allows systematic analysis of how the output varies as multiple variables change simultaneously. Such functions frequently arise in physical models and optimization problems, where system behavior depends on several interacting...
Double Integrals Over General Regions01:18

Double Integrals Over General Regions

Double integrals are often used to measure quantities distributed across two-dimensional regions, such as rainfall over a lake, heat across a metal plate, or population density over land. In many practical situations, the region of interest does not have straight boundaries and cannot be described conveniently as a rectangle. Instead, the region may have curved or irregular edges. To evaluate integrals over such domains, the region is embedded inside a larger rectangular region where...