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Coumarins: macrophage proteinase production and pinocytosis
K R Knight1, G Vairo, J A Hamilton
1Microsurgery Research Centre, St. Vincent's Hospital, Melbourne, Australia.
Research in Experimental Medicine. Zeitschrift Fur Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie
|January 1, 1992
Abstract:
Coumarins, which are thought to stimulate macrophage proteinase activity, have been advocated for the treatment of high protein oedemas, such as obstructive lymphoedema. In experiments with cultured murine macrophages, coumarin and 7-hydroxycoumarin (10(-3) or 10(-4) M) had no significant effect on plasminogen-activator activity, plasminogen-independent fibrinolytic activity or pinocytosis. Although no in vitro effect on macrophage proteinase activity was found, it is possible that coumarins activate other cell types in vivo and thus effectively treat lymphoedema.