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Related Experiment Videos

Behavioural disorders induced by external globus pallidus dysfunction in primates: I. Behavioural study.

David Grabli1, Kevin McCairn, Etienne C Hirsch

  • 1Neurologie et Thérapeutique expérimentale, INSERM U289, Hôpital de la Salpêtrière, Paris, France.

Brain : a Journal of Neurology
|August 5, 2004
PubMed
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This study shows that specific parts of the external globus pallidus (GPe) in monkeys are linked to distinct behaviors. Targeting the limbic GPe caused stereotypy, while the associative GPe led to attention deficits or hyperactivity, supporting basal ganglia functional partitioning.

Area of Science:

  • Neuroscience
  • Behavioral Neuroscience
  • Primate Models

Background:

  • The basal ganglia are functionally partitioned into sensorimotor, associative, and limbic territories.
  • Evidence for non-motor territories' roles is limited, often relying on clinical observations.
  • Previous studies showed sensorimotor GPe dysfunction causes abnormal movements in monkeys.

Purpose of the Study:

  • To investigate the functional relevance of associative and limbic territories of the external globus pallidus (GPe).
  • To test the hypothesis that GPe dysfunction in non-motor territories induces behavioral disorders, not movement abnormalities.
  • To establish a primate model for disorders linked to basal ganglia dysfunction.

Main Methods:

  • Microinjections of bicuculline were administered into sensorimotor, associative, and limbic territories of the GPe in monkeys.

Related Experiment Videos

  • Spontaneous behavior and task performance were assessed during bicuculline effects.
  • Control injections included surrounding structures and saline into the GPe.

    • Main Results:

    • Limbic GPe microinjections induced stereotyped behaviors.
    • Associative GPe microinjections resulted in attention deficits and/or hyperactivity.
    • Sensorimotor GPe injections produced abnormal movements, as expected.
    • No effects were observed in control injections.

    Conclusions:

    • The external globus pallidus exhibits functional diversity and territorial specificity.
    • Results support the parallel circuits model of basal ganglia organization.
    • The findings provide experimental evidence for basal ganglia involvement in Tourette's syndrome, ADHD, and compulsive disorders.
    • This study offers a potential primate model for these neuropsychiatric conditions.