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Related Experiment Videos

Oesophageal pH-metry: should meals be standardized?

F Castiglione1, C Emde, D Armstrong

  • 1Division of Gastroenterology, CHUV, Lausanne, Switzerland.

Scandinavian Journal of Gastroenterology
|May 1, 1992
PubMed
Summary

A late-evening, high-fat meal significantly increased nocturnal gastro-oesophageal reflux in healthy volunteers. This suggests meal composition and timing are crucial factors influencing oesophageal acid exposure.

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Area of Science:

  • Gastroenterology
  • Digestive Health
  • Clinical Nutrition

Background:

  • Nocturnal gastro-oesophageal reflux is a common issue.
  • The impact of late-evening meals, particularly high-fat ones, on reflux is not fully understood.

Purpose of the Study:

  • To investigate the effect of a late-evening, high-fat meal on nocturnal supine gastro-oesophageal reflux.
  • To compare reflux parameters after a high-fat meal versus a standardized light meal.

Main Methods:

  • Eight healthy volunteers participated in the study.
  • Ambulatory oesophageal pH-metry recordings were performed twice.
  • Recordings were taken after a standardized light meal and a high-fat meal (including peppermint and chocolate) consumed late in the evening.

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Main Results:

  • The high-fat meal significantly increased median acid exposure time (7.9% vs 0.0%) and the median number of reflux episodes (7 vs 0) during supine hours (2300-0700).
  • Persistent nocturnal reflux was predominantly observed after the high-fat meal.
  • Reflux occurred after both meal types, but was more pronounced and sustained after the high-fat meal.

Conclusions:

  • Late-evening, high-fat meals can exacerbate nocturnal supine gastro-oesophageal reflux.
  • Meal composition and timing are important considerations when analyzing oesophageal pH recordings.
  • Dietary choices, especially late at night, may play a significant role in managing acid reflux symptoms.