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Related Experiment Videos

Experimental dynamic cardiomyoplasty in sheep.

S Thelin1, S Vedung, U Nylund

  • 1Department of Thoracic and Cardiovascular Surgery, University Hospital, Uppsala, Sweden.

Scandinavian Journal of Thoracic and Cardiovascular Surgery
|January 1, 1992
PubMed
Summary

Electrically stimulated latissimus dorsi (LD) muscle grafts show potential for augmenting ventricular function in heart failure. Chronic stimulation transforms LD muscle into a fatigue-resistant type, improving its capacity to assist a failing heart.

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Area of Science:

  • Cardiovascular Surgery
  • Regenerative Medicine
  • Skeletal Muscle Physiology

Background:

  • Cardiac insufficiency significantly impairs ventricular function.
  • Muscle grafts offer a potential therapeutic avenue for cardiac repair.
  • Dynamic cardiomyoplasty utilizes skeletal muscle to support cardiac function.

Purpose of the Study:

  • To evaluate the efficacy of electrically stimulated latissimus dorsi (LD) muscle grafts for augmenting ventricular function in cardiac insufficiency.
  • To assess the histochemical and biochemical changes in LD muscle following chronic electrical stimulation.
  • To determine the hemodynamic benefits of dynamic cardiomyoplasty in a sheep model of heart failure.

Main Methods:

  • Dynamic cardiomyoplasty was performed in nine sheep, wrapping the LD muscle around the left ventricle.

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  • Postoperative electrical stimulation of the LD muscle was initiated 2 weeks post-surgery, synchronized with the heart.
  • Hemodynamic evaluations and muscle biopsies were conducted at 6 and 12 weeks for histochemical and biochemical analysis.

    • Main Results:

    • Cardiomyoplasty increased cardiac output by 25% in two sheep during induced heart failure.
    • Eight out of nine LD muscles demonstrated vigorous contraction synchronized with the heart.
    • Histochemical analysis revealed a transformation of muscle fibers to fatigue-resistant Type I, with increased oxidative and decreased glycolytic enzymes.

    Conclusions:

    • Chronic electrical stimulation effectively modifies LD muscle characteristics towards an oxidative, fatigue-resistant phenotype.
    • This transformation enhances the potential of muscle grafts to assist a depressed heart.
    • Dynamic cardiomyoplasty presents risks including adhesions and muscle trauma from stimulation.