Hypertrophic pulmonary osteoarthropathy: control of pain and symptoms with pamidronate
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Updated: Aug 23, 2026

Osteopathic Manipulative Treatment as a Useful Adjunctive Tool for Pneumonia
Published on: May 6, 2014
Howard Amital1, Yaakov H Applbaum, Lena Vasiliev
1Rheumatology Unit, Department of Radiology and Division of Internal Medicine, Hadassah-Hebrew University School of Medicine, Ein-Karem, POB 12000, 91120 Jerusalem, Israel. amitalh@netvision.net.il
Abstract:
This case presents a patient with hypertrophic osteoarthropathy of the lower extremities that developed secondary to congenital cyanotic heart disease. The major clinical manifestation was severe bilateral leg pain. The pain that was debilitating in nature completely resolved following a single administration of 60 mg pamidronate. Hypertrophic osteoarthropathy (HOA) is an acquired, uncommon disorder of obscure etiology. It has been described mainly in association with chronic suppurative pulmonary diseases, bronchogenic carcinoma and lung metastases, cystic fibrosis, and cyanotic congenital malformations of the heart.
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