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[Palpable purpura].

R Hoigné, T Hunziker

Schweizerische Medizinische Wochenschrift

|August 29, 1992

Summary

This summary is machine-generated.

Drug-induced leukocytoclastic vasculitis often presents as skin lesions only. Henoch-Schönlein purpura, involving multiple organs, is less frequently linked to drug causes.

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Area of Science:

Dermatology
Rheumatology
Clinical Pharmacology

Background:

Cutaneous leukocytoclastic vasculitis is characterized by non-thrombocytopenic palpable purpura.
Henoch-Schönlein purpura involves skin lesions along with gastrointestinal, kidney, and/or joint manifestations.

Purpose of the Study:

To investigate the association between drug etiology and leukocytoclastic vasculitis, differentiating between skin-limited and multi-organ involvement.

Main Methods:

Retrospective analysis of 27,510 inpatients from 1974-1989.
Comparison of drug-related causes in skin-limited vasculitis versus Henoch-Schönlein purpura.

Main Results:

Two patients developed drug-related leukocytoclastic vasculitis limited to the skin; one patient had multiple episodes.

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In contrast, only one of eight Henoch-Schönlein purpura cases suspected a drug etiology.

Drug etiology was more strongly suspected in skin-limited leukocytoclastic vasculitis.

Conclusions:

Drug-induced leukocytoclastic vasculitis should be considered in all cases.
Drug etiology is more likely validated in patients with skin-limited leukocytoclastic vasculitis.