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Updated: Jul 31, 2026

Synthesis and Purification of Iodoaziridines Involving Quantitative Selection of the Optimal Stationary Phase for Chromatography
Published on: May 16, 2014
Chiral resolution of some piperidine 2, 6-dione drugs by high performance liquid chromatography on Kromasil CHI-DMB
1Biological and Medical Research Department, King Faisal Specialist Hospital and Research Centre, Saudi Arabia. enein@kfshrc.edu.sa
Abstract:
Kromasil CHI-DMB chiral stationary phase (CSP) is used to resolve some piperidine-2, 6-diones under normal mobile phase mode. Base-line separation was achieved using hexane and dioxane (90 : 10 v/v) for aminoglutethimide (AG), pyridoglutethimide (PG), cyclohexylaminoglutethimide (ChAG), thioglutethimide (TG), and N-acetyl aminoglutethimide (AAG). The chromatographic parameters are reported. The chiral recognition mechanisms between the analytes and the CSP depend primarily on hydrogen bonding and/or (pi-pi) interactions.
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