[Oxidative stress in the pathogenesis of anti-phospholipid syndrome]

Summarized in the paper are the data describing the significance of the oxidative stress within the pathogenesis of anti-phospholipid syndrome (APS). The mechanisms related with formation of active oxygen metabolites in human body, triggers of the oxidative stress as well as its involvement in the APS pathogenesis (i.e. in the aPL synthesis), in the endothelial malfunction development and in the development of pro-coagulation impairments within the hemostasis system leading to thrombosis are in the focus of attention. Approaches to treatment schemes of vascular disorders in APS comprising the oxidative stress correction are suggested.