Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Metabolic flexibility.

Len Storlien1, Nick D Oakes, David E Kelley

  • 1AstraZeneca R&D, Pepparedsleden 3, Mölndal 431 83, Sweden. leonard.storlien@astrazeneca.com

The Proceedings of the Nutrition Society
|August 6, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of weight loss on testosterone, sex hormone-binding globulin, adiposity, and insulin sensitivity in women and men.

Obesity (Silver Spring, Md.)·2025
Same author

Author Correction: Functionally selective signaling and broad metabolic benefits by novel insulin receptor partial agonists.

Nature communications·2024
Same author

Discovery of Insulin Receptor Partial Agonists MK-5160 and MK-1092 as Novel Basal Insulins with Potential to Improve Therapeutic Index.

Journal of medicinal chemistry·2022
Same author

Functionally selective signaling and broad metabolic benefits by novel insulin receptor partial agonists.

Nature communications·2022
Same author

Muscle insulin resistance in type 1 diabetes with coronary artery disease.

Diabetologia·2020
Same author

PAN-AMPK Activation Improves Renal Function in a Rat Model of Progressive Diabetic Nephropathy.

The Journal of pharmacology and experimental therapeutics·2019
Same journal

Misled or misfed: Nutrition claims targeting active females on social media, is there research evidence to support them?

The Proceedings of the Nutrition Society·2026
Same journal

Whole-body metabolic modelling and its prospects in precision nutrition.

The Proceedings of the Nutrition Society·2026
Same journal

Culturally adapted multimodal lifestyle approaches for metabolic dysfunction-associated steatotic liver disease: role of diet, physical activity and sleep.

The Proceedings of the Nutrition Society·2026
Same journal

Is it time for a shake-up of the Eatwell Guide? What do Dietitians, Nutritionists and other Health Professionals want?

The Proceedings of the Nutrition Society·2026
Same journal

Optimizing Adherence and Outcomes: Potential Strategies to Enhance the Effectiveness of nutrient-stimulated hormone therapies.

The Proceedings of the Nutrition Society·2026
Same journal

Microbial biosynthesis of vitamin D<sub>2</sub>.

The Proceedings of the Nutrition Society·2026
See all related articles

Metabolic flexibility, the ability to switch between fuel sources like lipids and carbohydrates, is crucial for human health. Loss of this metabolic flexibility is a key issue in metabolic syndrome, obesity, and diabetes.

Area of Science:

  • Human Physiology
  • Metabolic Regulation

Background:

  • Metabolic flexibility, the capacity to utilize and transition between lipid and carbohydrate fuels, characterizes healthy human physiology.
  • Metabolic inflexibility is increasingly recognized as a central dysfunction in metabolic syndrome, obesity, and diabetes.

Purpose of the Study:

  • To explore the manifestations and implications of metabolic inflexibility in obese and diabetic individuals.
  • To identify key questions regarding the loss and potential recovery of metabolic flexibility.

Main Methods:

  • The study reviews evidence linking metabolic inflexibility to specific dysfunctions in obese and diabetic states.
  • It examines impaired fuel utilization in tissues like skeletal muscle, characterized by reduced mitochondrial capacity.

Related Experiment Videos

Main Results:

  • Metabolic inflexibility manifests as impaired insulin secretion, altered fuel use in skeletal muscle, and dysregulated fatty acid metabolism.
  • Reduced mitochondrial size and density in skeletal muscle are identified as characteristic of metabolic syndrome and metabolic inflexibility.

Conclusions:

  • Metabolic inflexibility is a significant factor in the pathophysiology of metabolic syndrome, obesity, and diabetes.
  • Further research is needed to understand the mechanisms of metabolic flexibility loss and to develop strategies for its restoration.