Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

A calcium-based phantom bursting model for pancreatic islets.

Richard Bertram1, Arthur Sherman

  • 1Department of Mathematics and Kasha Laboratory of Biophysics, Florida State University, Tallahassee, Florida 32306, USA.

Bulletin of Mathematical Biology
|August 6, 2004
PubMed
Summary

Mathematical models of insulin-secreting beta-cells, using a phantom bursting mechanism, explain diverse burst frequencies. This approach utilizes intracellular calcium and multiple slow processes for accurate beta-cell behavior simulation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evidence that interglomerular inhibition generates non-monotonic concentration-response relationships in mitral/tufted glomeruli in the mouse olfactory bulb.

The Journal of physiology·2026
Same author

Erg currents support electrical bursting in murine anterior pituitary corticotrophs.

The Journal of physiology·2026
Same author

African immigrants with type 2 diabetes present with three physiologic subtypes: implications for screening, diagnosis and treatment.

BMJ open diabetes research & care·2026
Same author

A novel disposition index without insulin is an earlier and sensitive predictor of type 2 diabetes than current diagnostic criteria.

Diabetes research and clinical practice·2026
Same author

Predictive Value of 1-Hour Glucose Elevations during Oral Glucose Tolerance Testing for Cystic Fibrosis-Related Diabetes.

Pediatric diabetes·2025
Same author

Evidence that interglomerular inhibition generates non-monotonic concentration-response relationships in mitral/tufted glomeruli in the mouse olfactory bulb.

bioRxiv : the preprint server for biology·2025

Area of Science:

  • * Computational biology
  • * Mathematical modeling
  • * Cell physiology

Background:

  • * Pancreatic beta-cells are excitable cells crucial for glucose regulation.
  • * Mathematical models are essential for understanding beta-cell dynamics.
  • * Phantom bursting models explain varied islet burst frequencies through slow process interactions.

Purpose of the Study:

  • * To implement and analyze a phantom bursting model for beta-cells.
  • * To investigate the role of intracellular calcium in controlling oscillations.
  • * To extend fast/slow analysis for understanding complex bursting patterns.

Main Methods:

  • * Developed a mathematical model incorporating intracellular calcium feedback.
  • * Utilized extended fast/slow analysis to interpret model dynamics.

Related Experiment Videos

  • * Simulated beta-cell responses to glucose and calcium perturbations.

    • Main Results:

    • * The model successfully reproduces a wide range of beta-cell bursting frequencies.
    • * Intracellular calcium oscillations are controlled by direct and indirect negative feedback.
    • * The model accounts for experimental observations like the triphasic glucose response.

    Conclusions:

    • * Phantom bursting models offer a framework for understanding beta-cell electrical activity.
    • * Multiple slow processes and intracellular calcium are key to bursting dynamics.
    • * This model provides design principles for future beta-cell research.