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Second-generation biopharmaceuticals.

Gary Walsh1

  • 1Department of Chemical and Environmental Sciences, Industrial Biochemistry Program, University of Limerick, Limerick, Ireland. gary.walsh@ul.ie

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V
|August 7, 2004
PubMed
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First-generation biopharmaceuticals are unengineered proteins. Modern engineered biopharmaceuticals offer improved properties by altering protein structure, leading to advanced therapeutic options.

Area of Science:

  • Biochemistry
  • Protein Engineering
  • Pharmacology

Background:

  • First-generation biopharmaceuticals often consist of unengineered murine monoclonal antibodies or simple replacement proteins.
  • These products mimic native human proteins in their amino acid sequence.

Purpose of the Study:

  • To discuss the evolution of biopharmaceuticals from first-generation to engineered second-generation products.
  • To highlight the methods and applications of protein engineering in biopharmaceutical development.

Main Methods:

  • Review of current biopharmaceutical engineering strategies.
  • Analysis of alterations in amino acid sequence, glycosylation, and chemical modifications (e.g., polyethylene glycol attachment).

Main Results:

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  • A significant trend towards engineered, second-generation biopharmaceuticals is observed.
  • Engineering aims to modify immunological or pharmacokinetic profiles and create novel fusion proteins.

Conclusions:

  • Protein engineering is crucial for developing advanced biopharmaceuticals.
  • Future advancements will rely on a deeper understanding of protein structure-function relationships for novel therapeutic development.