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Polysaccharide-decorated nanoparticles.

Caroline Lemarchand1, Ruxandra Gref, Patrick Couvreur

  • 1UMRCNRS 8612, School of Pharmacy, Université Paris Sud, Châtenay Malabry, France.

European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Fur Pharmazeutische Verfahrenstechnik E.V
|August 7, 2004
PubMed
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Polysaccharide coatings on nanoparticles enhance drug delivery by improving circulation time, targeting tumors, and boosting absorption through nasal or ocular routes. These modified nanoparticles also show potential for delivering genetic material like DNA.

Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Drug Delivery

Background:

  • Surface-modified colloidal carriers, like nanoparticles, can alter drug biodistribution and absorption.
  • Polysaccharides are versatile biopolymers for nanoparticle surface modification.

Purpose of the Study:

  • To review strategies for coating nanoparticles with polysaccharides.
  • To highlight medical applications and drug absorption enhancement by these modified nanoparticles.

Main Methods:

  • Physicochemical and biological methods for demonstrating polysaccharide surface modification.
  • Review of literature on polysaccharide-coated nanoparticles for medical applications.

Main Results:

  • Polysaccharide coatings increase nanoparticle blood circulation time and enable targeting of specific tumoral tissues for cancer imaging.

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  • Coatings improve drug absorption via nasal and ocular routes due to mucoadhesive and permeability enhancer properties.
  • Polysaccharide-coated nanoparticles demonstrate potential for delivering DNA and oligonucleotides.

    • Conclusions:

    • Surface modification of nanoparticles with polysaccharides offers significant advantages for drug delivery and medical imaging.
    • These coatings enhance therapeutic efficacy through improved pharmacokinetics and targeted delivery.
    • Polysaccharide-coated nanoparticles represent a promising platform for advanced therapeutic applications, including gene delivery.