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Sudden progression of a glioblastoma in partial remission?

H Lins1, D Kanakis, T Heinrichs

  • 1Department of Neurology, Klinikum der Otto-von-Guericke-Universität, Leipziger Str. 44, D-39120 Magdeburg, Germany. hartmut.lins@medizin.uni-magdeburg.de

Clinical Neurology and Neurosurgery
|August 7, 2004
PubMed

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Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...