Related Experiment Video
Updated: Aug 23, 2026

RiboTag Immunoprecipitation in the Germ Cells of the Male Mouse
Published on: March 4, 2020
Linkage mapping of the locus responsible for male pseudohermaphroditism (mp) on rat chromosome 7
Yasuhiro Kawai1, Yuriko Takeno, Eiji Kobayashi
1Graduate School of Natural Science and Technology, Okayama University, Japan.
Abstract:
TF is a mutant rat strain showing male pseudohermaphroditism controlled by an autosomal single recessive gene (mp). The affected rats show lack of Leydig cells and androgen deficiency. In this study, we performed linkage analysis using F(2) progeny of crosses between TF and BN strains to determine the chromosomal localization of the mp locus. The mp locus was mapped in a 4 cM region of the distal region of rat chromosome 7 between D7Rat3 and D7Rat115 or D7Rat94. Comparison of the linkage map with corresponding regions of the published rat genome sequence revealed several candidate genes for the mp mutation, including the Dhh, Tegt, Gdp3, and Amhr2 genes.
Related Concept Videos
The Y Chromosome Determines Maleness
Evolution
Around 300 million years ago, the two sex chromosomes diverged from two identical autosomal chromosomes. Over time, the Y chromosome has lost most of its genes, shrinking in size. Today,...
Epistasis
Pedigree Analysis
Dosage Compensation
In addition to sexual development, the X chromosome has genes involved in autosomal functions such as brain development and the immune system. Therefore, males and females with distinct numbers of X chromosomes will have...
The Ratio of X Chromosome to Autosomes
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female Drosophila...
X-linked Traits

