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Incidence of myasthenia gravis in the province of Ferrara: a community-based study
I Casetta1, E Fallica, V Govoni
1Sezione di Clinica Neurologica, Dipartimento di Discipline Medico Chirurgiche della Comunicazione e del Comportamento, and Centro di Neuroscienze, Università degli Studi di Ferrara, Ferrara, Italy. cti@dns.unife.it
Background:
The reported annual incidence of myasthenia gravis (MG) ranges from 0.25 to 15 per million. The sex- and age-related pattern of disease incidence is still debated.
Methods:
An intensive descriptive study was performed in the province of Ferrara (mean population 360,950 people) over the period 1985 through 2000.
Results:
The average crude annual incidence rate was 2 per 100,000. We confirm a female preponderance in the total population, particularly in the youngest age groups.
Conclusions:
We observed an early increase in incidence in females, partly due to thymoma-associated MG, while MG without thymoma showed increasing incidence with age nonsignificantly different in the two sexes.
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