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[The first answer to viral infections: type I interferon]
Andreas Pichlmair1, Matthias Pollak, Andreas Bergthaler
1Abteilung Virologie, Institut für Medizinische Mikrobiologie und Hygiene, Universität Freiburg, Freiburg, Deutschland. andreas.pichlmair@cancer.org.uk
Berliner Und Munchener Tierarztliche Wochenschrift
|August 10, 2004
Summary
The interferon system provides innate immunity against viruses. This review covers interferon mechanisms, viral defenses, human therapies, and veterinary applications for diseases in various species.
Area of Science:
- Immunology
- Virology
Context:
- The interferon system is a critical component of the innate immune response in vertebrates, acting as the primary defense against viral infections.
- Interferons are signaling proteins that induce an antiviral state in neighboring cells, inhibiting viral replication.
Purpose:
- To summarize the molecular mechanisms of the interferon system and viral counteractions.
- To describe current type I interferon therapies in humans.
- To provide an overview of recent clinical studies and potential applications of interferons in veterinary medicine across various species.
Summary:
- This review details the molecular basis of the interferon system and how viruses evade it.
- It discusses established human therapies using interferons for viral, autoimmune, and neoplastic disorders.
- Recent veterinary clinical studies and the therapeutic potential of interferons in animals like cats, dogs, horses, cattle, sheep, pigs, and poultry are examined.
Impact:
- Provides a comprehensive overview of interferonology for both human and veterinary applications.
- Highlights the therapeutic potential and ongoing research of interferons in treating diseases across species.
- Informs clinical decisions regarding the use of interferons in veterinary medicine.