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Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis
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Cystic fibrosis

Myra J Lewis1, Eugene H Lewis, Jean A Amos

  • 1Department of Pathology and Laboratory Medicine, Hartford Hospital, CT 06102, USA.

American Journal of Clinical Pathology
|August 10, 2004
PubMed

Insights

Pathologists use various techniques to study diseases like cystic fibrosis (CF), a complex genetic disorder. This review covers CF's pathology and molecular diagnostics for better disease understanding and patient care.

Area of Science:

  • Pathology
  • Genetics
  • Molecular Diagnostics

Background:

  • Pathologists analyze disease mechanisms using morphologic, immunologic, and molecular methods.
  • Cystic Fibrosis (CF) presents clinical heterogeneity, posing challenges for understanding genetic diseases.
  • Explaining CF's mechanisms is crucial for guiding clinical management.

Purpose of the Study:

  • To provide an overview of Cystic Fibrosis (CF).
  • To discuss the pathophysiologic features of CF.
  • To review the practical aspects of clinical and anatomic pathology in CF, including molecular diagnostics.

Main Methods:

  • Review of existing literature on Cystic Fibrosis.
  • Discussion of morphologic, immunologic, and molecular techniques used in pathology.
  • Analysis of pathophysiologic features relevant to CF.

Main Results:

  • Cystic Fibrosis (CF) is a complex genetic disease with significant heterogeneity.
  • Pathological examination is key to understanding CF mechanisms.
  • Molecular diagnostics play a vital role in CF management.

Conclusions:

  • Pathology is essential for unraveling the complexities of genetic diseases like CF.
  • Understanding CF's pathophysiology aids in clinical decision-making.
  • Molecular diagnostic advancements are critical for the future of CF care.

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