Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

3D MRI-based multicomponent FSI models for atherosclerotic plaques.

Dalin Tang1, Chun Yang, Jie Zheng

  • 1Mathematical Sciences Department, Worcester Polytechnic Institute, Worcester, MA 01609, USA. dtang@wpi.edu

Annals of Biomedical Engineering
|August 10, 2004
PubMed
Summary

Computational models reveal that large lipid pools and thin plaque caps in atherosclerotic plaques are linked to extreme stress and strain, potentially indicating rupture risk. Further studies are needed to validate these findings for plaque vulnerability assessment.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Patient-Specific MRI-Based Right Ventricle Models Using Different Zero-Load Diastole and Systole Geometries for Better Cardiac Stress and Strain Calculations and Pulmonary Valve Replacement Surgical Outcome Predictions.

PloS one·2016
Same author

Crossover phenomena of percolation transition in evolution networks with hybrid attachment.

Chaos (Woodbury, N.Y.)·2016
Same author

Relation Between C-X-C Motif Chemokine Receptor 4 Levels and the Presence and Extent of Angiographic Coronary Collaterals in Patients With Chronic Total Coronary Occlusion.

The American journal of cardiology·2016
Same author

Quantify patient-specific coronary material property and its impact on stress/strain calculations using in vivo IVUS data and 3D FSI models: a pilot study.

Biomechanics and modeling in mechanobiology·2016
Same author

Analysis of Genomewide DNA Methylation Reveals Differences in DNA Methylation Levels between Dormant and Naturally as well as Artificially Potentiated Pedicle Periosteum of Sika Deer (Cervus nippon).

Journal of experimental zoology. Part B, Molecular and developmental evolution·2016
Same author

Value of corneal epithelial and Bowman's layer vertical thickness profiles generated by UHR-OCT for sub-clinical keratoconus diagnosis.

Scientific reports·2016

Area of Science:

  • Biomedical Engineering
  • Computational Fluid Dynamics
  • Cardiovascular Research

Background:

  • Atherosclerosis involves plaque buildup in arteries, increasing rupture risk.
  • Understanding plaque mechanics is crucial for predicting cardiovascular events.

Purpose of the Study:

  • To develop and utilize a 3D MRI-based computational model to analyze the mechanical behavior of human atherosclerotic plaques.
  • To identify critical flow and stress/strain conditions associated with plaque rupture.

Main Methods:

  • Reconstructed 3D geometry of a human carotid plaque from MRI data.
  • Generated computational mesh and applied hyperelastic, isotropic, incompressible, and homogeneous material properties for artery wall and plaque components.
  • Simulated laminar, Newtonian, viscous, and incompressible flow using a fully coupled fluid-structure interaction (FSI) model solved by the ADINA finite element package.

Related Experiment Videos

  • Compared results from 2D and 3D models under varying pressure and axial stretch conditions.

    • Main Results:

    • Identified associations between large lipid pools, thin plaque caps, and extreme stress/strain levels (both maximum and minimum).
    • Observed significant cyclic stress/strain variations within the plaque under pulsating pressure.
    • These variations suggest potential for artery fatigue and plaque rupture.

    Conclusions:

    • The computational model provides insights into plaque mechanics and vulnerability.
    • Large lipid pools and thin caps are mechanical indicators of potential plaque rupture.
    • Further large-scale patient studies are recommended for validation and clinical application in plaque vulnerability assessment and rupture prediction.