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Published on: March 7, 2025

Helicobacter pylori eradication decreases blood neutrophil and monocyte counts

Y Kondo1, T Joh, M Sasaki

  • 1Department of Internal Medicine and Bioregulation, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.

Alimentary Pharmacology & Therapeutics
|August 10, 2004
PubMed

Insights

Helicobacter pylori infection elevates neutrophil and monocyte counts, impacting systemic health. Eradicating H. pylori normalizes these levels, but smoking may obscure this effect.

Area of Science:

  • Medical research
  • Gastroenterology
  • Hematology

Background:

  • The systemic impact of Helicobacter pylori infection remains unclear.
  • Investigating H. pylori's role in systemic disorders is crucial.

Purpose of the Study:

  • To determine the systemic effects of H. pylori infection.
  • Compare peripheral blood leukocyte and platelet counts before and after H. pylori eradication.

Main Methods:

  • Retrospective analysis of 164 H. pylori-positive patients undergoing eradication therapy.
  • Monitoring peripheral blood leukocyte and platelet populations at multiple time points post-eradication.

Main Results:

  • H. pylori eradication significantly decreased leukocytes, neutrophils, and monocytes in non-smokers.
  • No significant changes observed in lymphocytes, eosinophils, basophils, or platelets.
  • Smoking appeared to mask the reduction in leukocytes and neutrophils post-eradication.

Conclusions:

  • H. pylori infection elevates peripheral neutrophil and monocyte counts, suggesting a role in systemic disorders.
  • Smoking may confound the observed effects of H. pylori eradication on peripheral leukocytes.
Abstract

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