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Indometacin up-regulates TFF2 expression in gastric epithelial cells

A Koitabashi1, T Shimada, Y Fujii

  • 1Department of Gastroenterology and Institute for Medical Science, Dokkyo University School of Medicine, Mibu, Tochigi, Japan.

Alimentary Pharmacology & Therapeutics
|August 10, 2004
PubMed
Summary

Non-steroidal anti-inflammatory drugs (NSAIDs) like indometacin increase trefoil factor 2 (TFF2) expression in gastric cells. This TFF2 upregulation may protect against NSAID-induced gastric damage via a COX-independent pathway.

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