Related Experiment Video

Updated: Aug 23, 2026

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter
11:32

Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter

Published on: March 27, 2020

ETS transcription factors: possible targets for cancer therapy

Tsuneyuki Oikawa1

  • 1Department of Cell Genetics, Sasaki Institute, Chiyoda-ku, Tokyo 101-0062, Japan. oikawa@sasaki.or.jp

Cancer Science
|August 10, 2004
PubMed

Insights

Ets family (ETS) transcription factors regulate key cellular processes. Their deregulation is linked to cancer, suggesting ETS genes as potential therapeutic targets for selective cancer therapy.

Area of Science:

  • Molecular Biology
  • Genetics
  • Cancer Research

Background:

  • Ets family (ETS) transcription factors possess a conserved Ets domain crucial for cellular functions.
  • ETS genes are downstream targets of Ras-MAP kinase signaling pathways.
  • Deregulation of ETS genes contributes to malignant cell transformation.

Purpose of the Study:

  • To investigate the role of Ets family transcription factors in cell development, differentiation, proliferation, apoptosis, and tissue remodeling.
  • To explore the involvement of ETS genes in human malignancies, including leukemia and Ewing tumors.
  • To evaluate the potential of ETS transcription factors as molecular targets for cancer therapy.

Main Methods:

  • Analysis of Ets family (ETS) transcription factors' conserved Ets domain.
  • Investigation of Ras-MAP kinase signaling pathways.
  • Examination of ETS gene rearrangements in human leukemia and Ewing tumors.
  • Assessment of aberrant ETS gene expression in various human malignant tumors.

Main Results:

  • ETS transcription factors are vital for normal cellular processes.
  • Rearrangement of ETS genes leads to chimeric oncoproteins in certain cancers.
  • Abnormal expression of ETS genes is frequently observed in human cancers.
  • ETS factors contribute to cancer progression, including invasion, metastasis, and neo-angiogenesis.

Conclusions:

  • Ets family transcription factors play a significant role in both normal cellular functions and malignant transformation.
  • The involvement of ETS genes in cancer progression highlights their potential as therapeutic targets.
  • Targeting ETS transcription factors may offer a strategy for selective cancer therapy.

More Related Videos

Generating the Transcriptional Regulation View of Transcriptomic Features for Prediction Task and Dark Biomarker Detection on Small Datasets03:37

Generating the Transcriptional Regulation View of Transcriptomic Features for Prediction Task and Dark Biomarker Detection on Small Datasets

Published on: March 1, 2024

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis09:58

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis

Published on: June 27, 2020

Related Concept Videos

Master Transcription Regulators02:23

Master Transcription Regulators

Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a  complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
Transcription Factors02:16

Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
Transcription Factors02:16

Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
General Transcription Factors01:30

General Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...