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Thrombophilia in coronary artery disease: a double jeopardy

D Mohanty1, K Ghosh, A Khare

  • 1Institute of Immunohaematology (ICMR), Mumbai, India. mohanty@bom5.vsnl.net.in

The Indian Journal of Medical Research
|August 10, 2004
PubMed

Insights

Thrombophilia, an increased thrombosis risk, involves haemostasis disruption. Investigating thrombophilia in Indian young myocardial infarction patients is crucial due to rising cases and lack of conventional risk factors.

Area of Science:

  • Cardiology
  • Hematology
  • Genetics

Background:

  • Thrombophilia signifies an elevated risk of thrombosis, stemming from genetic or environmental haemostasis perturbations.
  • Coronary artery disease (CAD) pathogenesis involves atheroma development, leading to angina and myocardial infarction (MI).
  • Emerging research explores blood coagulation factors, natural anticoagulants, platelet antigens, homocysteine, and lipoprotein (a) in arterial thrombosis and CAD risk.

Purpose of the Study:

  • To investigate the role of thrombophilia in young Indian patients experiencing myocardial infarction (MI).
  • To address the rising incidence of MI in young Indians lacking traditional risk factors.
  • To evaluate the significance and cost-effectiveness of thrombophilia investigations in India.

Main Methods:

  • Review of existing literature on thrombophilia and its association with arterial thrombosis.
  • Analysis of studies on coagulation factors, natural anticoagulants, and other risk factors in CAD.
  • Consideration of clinical trial data on thrombophilia management.

Main Results:

  • Contradictory findings exist regarding the role of various factors in arterial thrombosis and CAD.
  • A notable increase in young MI patients in India is observed, often without conventional risk factors.
  • Limited studies on thrombophilia status among Indian populations highlight a knowledge gap.

Conclusions:

  • Thrombophilia is a significant consideration in unexplained MI, particularly in younger populations.
  • Cost-effective selection of thrombophilia investigations is paramount for developing countries like India.
  • Further research is needed to clarify the role of thrombophilia in the Indian context and guide management strategies.

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