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Expression profiling identifies chemokine (C-C motif) ligand 18 as an independent prognostic indicator in gastric cancer.

Suet Yi Leung1, Siu Tsan Yuen, Kent-Man Chu

  • 1Department of Pathology, The University of Hong Kong, Queen Mary Hospital, China. suetyi@hkucc.hku.hk

Gastroenterology
|August 10, 2004

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View abstract on PubMed

Summary

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  • Biomedical And Clinical Sciences
  • Oncology And Carcinogenesis
  • Predictive And Prognostic Markers
  • Expression Profiling Identifies Chemokine (c-c Motif) Ligand 18 As An Independent Prognostic Indicator In Gastric Cancer.
    • This summary is machine-generated.

    High levels of chemokine (C-C motif) ligand 18 (CCL18) in gastric cancer predict better survival. This macrophage-derived protein may serve as a therapeutic target and prognostic marker for patients.

    Area of Science:

    • Oncology
    • Immunology
    • Molecular Biology

    Background:

    • Gastric cancer is a significant global health concern.
    • Gene expression profiling is a valuable tool for identifying prognostic markers in cancer.
    • Previous studies identified potential prognostic genes in gastric adenocarcinoma.

    Purpose of the Study:

    • To investigate the prognostic role of chemokine (C-C motif) ligand 18 (CCL18) in gastric cancer.
    • To determine the cellular source and clinical significance of CCL18 expression.

    Main Methods:

    • Gene expression analysis using complementary DNA microarrays and quantitative reverse-transcription polymerase chain reaction.
    • Correlation of CCL18 expression with clinicopathologic and survival data (n=89 and n=59).
    • Immunohistochemistry and in situ hybridization to identify the cellular source of CCL18.

    Main Results:

    • High CCL18 expression was significantly associated with prolonged overall and disease-free survival in gastric cancer patients.
    • CCL18 levels, along with tumor stage, were independent prognostic factors.
    • CCL18 was found to be expressed by tumor-associated macrophages at the tumor invasion front.

    Conclusions:

    • Macrophage-derived CCL18 may act as an endogenous antitumor immunomodulator.
    • CCL18 presents a novel candidate for therapeutic intervention and risk stratification in gastric cancer.

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